Unmasking Mast Cell Activation Syndrome: Signs,Symptoms, and Root Causes

Mast Cell Activation Syndrome (MCAS) is often the missing link in patients with chronic, unexplained symptoms. Many people live with MCAS for years without realizing it’s the root cause of their fatigue, rashes, digestive issues, or anxiety. This condition occurs when mast cells—the immune cells that should protect you—become hyper-reactive and release histamine and other chemicals inappropriately, often in response to seemingly harmless triggers.

Dr. Chelsea Azarcon helps patients uncover hidden immune imbalances—like MCAS—that are often missed in conventional care. Her root-cause approach is especially effective for patients navigating complex conditions like Lyme disease, and Ehlers-Danlos Syndrome, where immune over activation is often part of the puzzle.

Understanding the Scope of MCAS

MCAS can affect multiple systems in the body, leading to a wide range of symptoms. It often overlaps with other chronic conditions, such as Lyme disease, Long COVID, POTS, and hypermobility syndromes like Ehlers-Danlos Syndrome (EDS). What they all share is immune dysregulation and inflammation driven by underlying triggers.

What Are the Symptoms?

Symptoms can vary widely and shift over time. They often include:

• Flushing, itching, hives

• Abdominal pain, bloating, diarrhea

• Sinus congestion, wheezing, shortness of breath

• Rapid heart rate, lightheadedness, low blood pressure

• Headaches, brain fog, fatigue, mood swings

Minor triggers include regular foods, scented products, temperature changes, or hormone fluctuations. Viral infections like COVID-19, Epstein-Barr (EBV), and Lyme disease can also activate mast cells and worsen symptoms.

Understanding and Managing Your Triggers

We help patients identify the root causes of MCAS activation—often including mold, viruses, parasites, chronic stress, hormone imbalance, gut infections, and food chemicals such as lectins, oxalates, and salicylates. Your personal triggers are likely unique, and discovering them is key to healing.

Treatment Support Options

Natural Mast Cell Stabilizers: Quercetin, luteolin, vitamin C, and DAO enzyme can all reduce histamine responses. We use professional-grade versions tailored to your needs.

Low Dose Naltrexone (LDN): This functional immune modulator is one of our go-to tools to calm chronic mast cell activation without harsh suppression.

Low-Histamine Diet Counseling: We provide hands-on support to reduce histamine exposure from food and identify individual food chemical sensitivities.

Air Quality Support: Mast cells respond to inhaled toxins. At home, we recommend HypoAir air purifiers (code: chelsea10) to reduce indoor triggers like mold, dust, and VOCs.

Why Personalized Care Matters

MCAS isn’t solved with a single pill—it requires a personalized, multi-layered approach. We support patients with:

• Lab testing to evaluate histamine and inflammatory markers

• Gut and microbiome repair strategies

• Hormone balancing

• Viral and environmental detox

• Genetic insights to tailor care (such as MTHFR or DAO variants)

  
  

You’re Not Alone—Let’s Get to the Root

If you’re dealing with unexplained symptoms that no one can explain—or if you’ve been diagnosed with MCAS and want better control—we can help. We specialize in root-cause investigation and building practical protocols that reduce reactivity and restore balance. We

specialize in calming immune overdrive and giving your body the tools to heal. If you’re ready to reduce reactivity, restore clarity, and feel safe in your own skin again, we’re here to help.